Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19046612 | 0.81 | GRM5 (0.58) | GRM5SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8315932 | 0.80 | MEN1 (0.57) | GRM5SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL11957019 | 0.80 | GRM5 (0.57) | GRM5SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL21078113 | 0.80 | GRM5 (0.57) | GRM5SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL11560889 | 0.80 | GRM5 (0.57) | GRM5SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL6382962 | 0.79 | GRM5 (0.56) | GRM5SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL9181047 | 0.79 | GRM5 (0.56) | GRM5SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL25292667 | 0.78 | GRM5 (0.55) | GRM5SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL6688964 | 0.78 | GRM5 (0.57) | GRM5SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL1709001 | 0.78 | GRM5 (0.55) | GRM5SMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |