Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18497293 | 0.86 | KMT2A (0.39) | SMN1; SMN2LMNAUSP2ALDH1A1NR1H2 | |
| SCHEMBL571404 | 0.82 | USP2 (0.42) | SMN1; SMN2USP2ALDH1A1NR1H2 | |
| SCHEMBL20826636 | 0.80 | USP2 (0.40) | SMN1; SMN2USP2ALDH1A1NR1H2 | |
| SCHEMBL20129092 | 0.77 | SPHK1 (0.44) | SMN1; SMN2SPHK1USP2NR1H2TLR8 | |
| SCHEMBL22906696 | 0.77 | SPHK1 (0.44) | SMN1; SMN2SPHK1USP2NR1H2TLR8 | |
| SCHEMBL6914197 | 0.77 | USP2 (0.40) | SMN1; SMN2USP2GPR119NR1H2 | |
| SCHEMBL19008242 | 0.76 | USP2 (0.42) | SMN1; SMN2SPHK1USP2NR1H2 | |
| SCHEMBL570830 | 0.76 | USP2 (0.42) | SMN1; SMN2USP2GPR119NR1H2 | |
| SCHEMBL18696436 | 0.76 | USP2 (0.42) | SMN1; SMN2USP2GPR119NR1H2 | |
| SCHEMBL21098215 | 0.76 | USP2 (0.34) | SMN1; SMN2LMNAUSP2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132770-A1 | TREATMENT OF KLEBSIELLA PNEUMONIAE INFECTIONS WITH ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS | ACHAOGEN, INC. (US) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010042850-A1 | ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS | ACHAOGEN, INC. (US) | 2010-04-15 | — | — | WO | disclosed |