Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11333828 | 0.98 | MEN1 (0.50) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL9532799 | 0.98 | MEN1 (0.50) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL2909988 | 0.98 | MEN1 (0.50) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL8455284 | 0.98 | MEN1 (0.50) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL11577648 | 0.98 | MEN1 (0.50) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL9386704 | 0.98 | MEN1 (0.50) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL8854283 | 0.98 | MEN1 (0.50) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL8499290 | 0.98 | MEN1 (0.50) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL6901492 | 0.98 | MEN1 (0.50) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL6906272 | 0.97 | MEN1 (0.48) | MEN1KMT2AKDM4CL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5069854-A | Pyrolysis of organoaluminum polymer, poly(acyloxy)aloxane, electroconductive | KYOTO INSTITUTE OF TECHNOLOGY (JP) | 1991-12-03 | — | — | US | claimed |
| US-20250326758-A1 | RICYCLIC HETEROARYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2025-10-23 | — | — | US | disclosed |
| US-12195470-B2 | 7-phenoxy-N-(3-azabicyclo[3.2.1]octan-8-yl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma- secretase modulators for the treatment of alzheimer's disease | HOFFMANN-LA ROCHE INC. (US) | 2025-01-14 | — | — | US | disclosed |
| EP-4424370-A2 | 7-PHENOXY-N-(3-AZABICYCLO[3.2.1LOCTAN-8-YL)-6,7-DIHYDRO-5H-PYRROLO[1,2-B][1,2,4]TRIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-09-04 | — | — | EP | disclosed |
| EP-3894411-B1 | 7-PHENOXY-N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)-6,7-DIHYDRO-5H-PYRROLO[1,2-B][1,2,4]TRIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2024-06-19 | — | — | EP | disclosed |
| WO-2024107929-A1 | CATALYTIC SYNTHESIS OF DELTA-VALEROLACTONE (DVL) FROM FURFURAL-DERIVED 2-HYDROXYTETRAHYDROPYRAN (HTHP) | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2024-05-23 | — | — | WO | disclosed |
| CN-117946116-A | 6, 7-Dihydro-5H-pyrrolo [1,2-B ] [1,2,4] triazol-2-amine derivatives | 豪夫迈·罗氏有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-113179641-B | 6, 7-dihydro-5H-pyrrolo [1,2-B ] [1,2,4] triazol-2-amine derivatives | 豪夫迈·罗氏有限公司 | 2024-01-02 | — | — | CN | disclosed |
| EP-3694830-B1 | PRODUCTION OF 1,5-PENTANEDIOL VIA UPGRADING OF TETRAHYDROFURFURYL ALCOHOL | WISCONSIN ALUMNI RES FOUND (US) | 2023-08-30 | — | — | EP | disclosed |
| US-20220056036-A1 | 7-PHENOXY-N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)-6,7-DIHYDRO-5H-PYRROLO[1,2-B][1,2,4]TRIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2022-02-24 | — | — | US | disclosed |
| WO-2014028723-A1 | IMPROVED CATALYSTS FOR HYDRODEOXYGENATION OF OXYGENATED HYDROCARBONS | VIRENT, INC. (US) | 2014-02-20 | — | — | WO | disclosed |
| WO-2013150534-A1 | NOVEL TARGETING AGENTS FOR DIAGNOSTIC AND THERAPEUTIC INDICATIONS | APOSENSE LTD. (IL) | 2013-10-10 | — | — | WO | disclosed |
| WO-2010042391-A2 | HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-04-15 | — | — | WO | disclosed |
| US-5069854-A | Pyrolysis of organoaluminum polymer, poly(acyloxy)aloxane, electroconductive | KYOTO INSTITUTE OF TECHNOLOGY (JP) | 1991-12-03 | — | — | US | disclosed |
| US-5069854-A | Pyrolysis of organoaluminum polymer, poly(acyloxy)aloxane, electroconductive | KYOTO INSTITUTE OF TECHNOLOGY (JP) | 1991-12-03 | — | — | US | disclosed |
| US-5051210-A | Electroconductive fiber of carbon in aluminum oxide formed by pyrolysis of polyacryloxyaloxane | KYOTO INSTITUTE OF TECHNOLOGY (JP) | 1991-09-24 | — | — | US | disclosed |
| EP-0170048-B1 | ALIPHATIC THIOETHERS | CIBA-GEIGY AG (CH) | 1991-04-17 | — | — | EP | disclosed |
| US-4649215-A | ANTIALLERGENS | CIBA-GEIGY CORPORATION (US) | 1987-03-10 | — | — | US | disclosed |
| EP-0170048-A2 | Aliphatic thioethers | CIBA-GEIGY AG (CH) | 1986-02-05 | — | — | EP | disclosed |
| US-4296042-A | Preparation of unsaturated aliphatic insect pheromones using cyclic phosphonium ylids | SYNTEX (U.S.A.) INC. (US) | 1981-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220056036-A1 | 7-PHENOXY-N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)-6,7-DIHYDRO-5H-PYRROLO[1,2-B][1,2,4]TRIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BACE1, PSEN1, APP | MEN1 206/4885KMT2A 2856/4885KDM4C 3753/4885 |
| US-12195470-B2 | 7-phenoxy-N-(3-azabicyclo[3.2.1]octan-8-yl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma- secretase modulators for the treatment of alzheimer's disease | BACE1, PSEN1, APP | MEN1 288/4885KMT2A 3048/4885KDM4C 3527/4885 |
| US-20250326758-A1 | RICYCLIC HETEROARYL DERIVATIVES | AR, CYP1B1, CYP1A1 | MEN1 295/4885KMT2A 605/4885KDM4C 1209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.