Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 2/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11205134 | 1.00 | MAPT (0.47) | MAPTHTTMMEACEALDH1A1 | |
| SCHEMBL287137 | 0.84 | ALDH1A1 (0.47) | MAPTHTTALDH1A1 | |
| SCHEMBL4090652 | 0.81 | HTT (0.68) | MAPTHTTALDH1A1L3MBTL1 | |
| SCHEMBL3076115 | 0.79 | EPHX2 (0.55) | — | |
| SCHEMBL910473 | 0.79 | EPHX2 (0.55) | — | |
| SCHEMBL3072384 | 0.79 | EPHX2 (0.55) | — | |
| SCHEMBL910474 | 0.79 | EPHX2 (0.55) | — | |
| SCHEMBL3069332 | 0.79 | MAPT (0.71) | MAPTALDH1A1CYP2C19 | |
| SCHEMBL3076773 | 0.79 | MAPT (0.71) | MAPTALDH1A1CYP2C19 | |
| SCHEMBL692819 | 0.79 | MAPT (0.71) | MAPTALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |