Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.36 |
| ▸ | OGA | O60502 | 2/20 | 0.35 |
| ▸ | PTAFR | P25105 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | CHRND | Q07001 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6797207 | 0.76 | GRM5 (0.52) | ACACBGRM5RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3347519 | 0.73 | GRM4 (0.46) | DYRK1AGRM5RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3346603 | 0.72 | GRM5 (0.41) | DYRK1AOGAGRM5RAB9ASMN1; SMN2 | |
| SCHEMBL3351686 | 0.72 | GRM5 (0.49) | DYRK1AOGAGRM5 | |
| SCHEMBL3346384 | 0.72 | GRM5 (0.43) | DYRK1AOGAGRM5RAB9ASMN1; SMN2 | |
| SCHEMBL3347789 | 0.72 | GRM5 (0.49) | DYRK1AOGAGRM5RAB9ASMN1; SMN2 | |
| SCHEMBL3346980 | 0.72 | GRM5 (0.49) | GRM5RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3346805 | 0.72 | DYRK1A (0.43) | DYRK1AGRM5RAB9APIK3CA | |
| SCHEMBL3348434 | 0.72 | GRM5 (0.54) | DYRK1AGRM5 | |
| SCHEMBL3347295 | 0.72 | GRM5 (0.48) | DYRK1AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |