Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26605091 | 0.78 | MAPT (0.37) | TSHRCYP3A4POLBSMN1; SMN2NPSR1 | |
| SCHEMBL14429883 | 0.72 | ALOX15 (0.44) | TSHRCYP3A4MAPTALDH1A1KDM4E | |
| SCHEMBL1745011 | 0.72 | ALOX15 (0.44) | TSHRCYP3A4MAPTALDH1A1KDM4E | |
| SCHEMBL1470334 | 0.71 | MEN1 (0.47) | TSHRPOLBMAPTALDH1A1KDM4E | |
| SCHEMBL17158279 | 0.70 | BRD4 (0.46) | TSHRCYP3A4POLBSMN1; SMN2NPSR1 | |
| SCHEMBL24162532 | 0.69 | ALOX15 (0.42) | TSHRCYP3A4MAPTALDH1A1KDM4E | |
| SCHEMBL28207345 | 0.69 | MAPT (0.34) | TSHRMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL9527406 | 0.69 | SLC6A2 (0.41) | TSHRCYP3A4MAPTALDH1A1MEN1 | |
| SCHEMBL12203632 | 0.69 | MEN1 (0.44) | TSHRPOLBMAPTALDH1A1KDM4E | |
| SCHEMBL10488163 | 0.68 | MAPT (0.39) | TSHRMAPTALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057865-A1 | N- INDEN- 2 -YL- ISOPROPYLSULFONAMIDES AS AMPA RECEPTOR POTENTIATORS | GLAXO GROUP LIMITED (GB) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010057865-A1 | N- INDEN- 2 -YL- ISOPROPYLSULFONAMIDES AS AMPA RECEPTOR POTENTIATORS | GLAXO GROUP LIMITED (GB) | 2010-05-27 | — | — | WO | disclosed |