Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Thiazolidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyruvate SCHEMBL14335413 | 0.91 | — | — | |
| Thiazolidine SCHEMBL7107836 | 0.90 | — | — | |
| Thiazolidine SCHEMBL3821706 | 0.90 | — | — | |
| Thiazolidine SCHEMBL16058281 | 0.85 | — | — | |
| Thiazolidine SCHEMBL10754857 | 0.85 | — | — | |
| Acetic Acid SCHEMBL8672783 | 0.82 | FFAR3 (0.37) | — | |
| Fumaric Acid SCHEMBL4951314 | 0.81 | TSHR (0.41) | — | |
| Fumaric Acid SCHEMBL1694365 | 0.81 | TSHR (0.41) | — | |
| Thiazolidine SCHEMBL131493 | 0.81 | — | — | |
| Thiazolidine SCHEMBL5484388 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009065797-A1 | PROCESS FOR OBTAINING MIXTURES OF 4-CARBOXY-1,3-THIAZOLIDINIUM CARBOXYLATE AND N-ACYL-1,3-THIAZOLIDIN-4-CARBOXYLIC ACID | UNIVERSITAT DE LLEIDA (ES) | 2009-05-28 | — | — | WO | claimed |
| WO-2025085030-A1 | SYNTHESIS OF SEMISYNTHETIC PENICILLIN DERIVATIVES CONTAINING HYDRAZONE-DERIVED THIAZOLIDINE AND IMIDAZOLE RING | ERCIYES UNIVERSITESI (TR) | 2025-04-24 | — | — | WO | disclosed |
| WO-2025085026-A1 | SYNTHESIS OF SEMISYNTHETIC PENICILLIN DERIVATIVES CONTAINING HYDRAZONE-DERIVED THIAZOLIDINE AND IMIDAZOLE RING | T.C. ERCIYES UNIVERSITESI (TR) | 2025-04-24 | — | — | WO | disclosed |
| CN-105998012-A | Diabetes treatment pharmaceutical composite and preparation method thereof | 苏州中化药品工业有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-105853383-A | Medicine composition for treating diabetic neuropathy and preparing method thereof | 苏州中化药品工业有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-1997638-B | 1,1' - (1, 2-acetylenediyl) bis-benzene derivatives as PTP1-B inhibitors | APPLIED RESEARCH SYSTEMS | 2011-07-06 | — | — | CN | disclosed |
| WO-2010056506-A1 | DIACYLGLYCEROL ACLYTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2009065797-A1 | PROCESS FOR OBTAINING MIXTURES OF 4-CARBOXY-1,3-THIAZOLIDINIUM CARBOXYLATE AND N-ACYL-1,3-THIAZOLIDIN-4-CARBOXYLIC ACID | UNIVERSITAT DE LLEIDA (ES) | 2009-05-28 | — | — | WO | disclosed |
| CN-100410236-C | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (CH) | 2008-08-13 | — | — | CN | disclosed |
| CN-101001642-A | Combination therapy for diabetes, obesity and cardiovascular disease using GDF-8 inhibitors | WYETH CORP (US) | 2007-07-18 | — | — | CN | disclosed |
| CN-1997638-A | 1, 1' - (1, 2-acetylenediyl) bis-benzene derivatives as PTP 1-B inhibitors | APPLIED RESEARCH SYSTEMS (AN) | 2007-07-11 | — | — | CN | disclosed |
| CN-1743321-A | Method for preparing thiazolidine acetate coprising phenyl propylidene | YANGZIJIANG PHARMACEUTICAL IND (CN) | 2006-03-08 | — | — | CN | disclosed |
| CN-1633410-A | Substituted methylene amide derivatives as protein tyrosine phosphatase modulators | APPLIED RESEARCH SYSTEMS (AN) | 2005-06-29 | — | — | CN | disclosed |
| CN-1477976-A | Combination of GABA agonists and aldose reductase inhibitors | �Ʒ� | 2004-02-25 | — | — | CN | disclosed |