Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | VDR | P11473 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346667 | 0.98 | HTT (0.59) | HTTSMN1; SMN2TDP1VDRKEAP1 | |
| SCHEMBL29261850 | 0.96 | HTT (0.58) | HTTSMN1; SMN2TDP1VDRKEAP1 | |
| Dimethylamine SCHEMBL29076612 | 0.93 | SMN1; SMN2 (0.54) | HTTSMN1; SMN2TDP1VDRKEAP1 | |
| SCHEMBL18282366 | 0.91 | HTT (0.72) | HTTSMN1; SMN2TDP1VDRKEAP1 | |
| SCHEMBL2237142 | 0.90 | TDP1 (0.67) | HTTSMN1; SMN2TDP1VDRKEAP1 | |
| Iodide SCHEMBL22068772 | 0.90 | CA2 (0.59) | HTTSMN1; SMN2TDP1CA12CA2 | |
| SCHEMBL18179825 | 0.88 | MEN1 (0.60) | HTTSMN1; SMN2TDP1CA12CA2 | |
| SCHEMBL4126086 | 0.88 | MEN1 (0.60) | HTTSMN1; SMN2TDP1CA12CA2 | |
| SCHEMBL9852204 | 0.88 | MEN1 (0.60) | HTTSMN1; SMN2TDP1CA12CA2 | |
| SCHEMBL24604538 | 0.87 | CA2 (0.62) | HTTSMN1; SMN2TDP1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114442426-A | Photoresist composition and pattern forming method | 罗门哈斯电子材料有限责任公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-109705012-B | Preparation method of 2, 5-diaryl five-membered heterocyclic aromatic hydrocarbon | 西北师范大学 | 2022-04-05 | — | — | CN | disclosed |
| WO-2010066357-A1 | BENZOTHIAZOLE AMIDES FOR DETECTION OF AMYLOID BETA | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-17 | — | — | WO | disclosed |