Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.37 |
| ▸ | GLRB | P48167 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23012593 | 0.84 | ATM (0.57) | ATMCYP2A6ALDH1A1GRM5CYP11B1 | |
| SCHEMBL28823048 | 0.84 | ATM (0.40) | ATMGRM5LMNAMAPTCYP2C9 | |
| SCHEMBL1477261 | 0.84 | CYP2C19 (0.57) | ATMALDH1A1GRM5LMNACA12 | |
| SCHEMBL6844757 | 0.84 | ATM (0.50) | ATMCYP2A6ALDH1A1GRM5CYP11B1 | |
| SCHEMBL19712252 | 0.83 | KDM4E (0.46) | ATMALDH1A1KDM4EGLRA3GLRB | |
| SCHEMBL15400163 | 0.83 | KDM4E (0.46) | ATMALDH1A1KDM4EGLRA3GLRB | |
| SCHEMBL27870359 | 0.81 | MKNK1 (0.40) | ATMCYP11B1CYP11B2MAPTL3MBTL1 | |
| SCHEMBL1477039 | 0.80 | MAPT (0.55) | ATMALDH1A1GRM5CYP11B1CYP11B2 | |
| SCHEMBL22120719 | 0.79 | ATM (0.51) | ATMCYP2A6ALDH1A1GRM5CYP11B1 | |
| SCHEMBL30234325 | 0.79 | ATM (0.51) | ATMCYP2A6ALDH1A1GRM5CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |
| US-5624943-A | Pyridine compounds which are useful as leukotriene-B4 -antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-04-29 | — | — | US | disclosed |
| EP-0651745-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B 4? ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002464-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B4 ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-02-03 | — | — | WO | disclosed |