Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347538 | 0.81 | ATM (0.58) | CYP11B2CYP11B1L3MBTL1MAPTATM | |
| SCHEMBL28823048 | 0.80 | ATM (0.40) | HCAR2NPC1RAB9AL3MBTL1DYRK1A | |
| SCHEMBL22531723 | 0.78 | GRM5 (0.38) | — | |
| SCHEMBL1477261 | 0.77 | CYP2C19 (0.57) | L3MBTL1MAPTATM | |
| SCHEMBL12478968 | 0.77 | GRM5 (0.55) | L3MBTL1NNMTMAPT | |
| SCHEMBL1479638 | 0.77 | GRM5 (0.56) | MKNK1MKNK2SIRT2SIRT1SIRT3 | |
| Hydrochloric Acid SCHEMBL1476861 | 0.75 | GRM5 (0.55) | MKNK1MKNK2SIRT2SIRT1SIRT3 | |
| SCHEMBL25093690 | 0.75 | NOS1 (0.44) | MKNK1MKNK2L3MBTL1NNMTMAPT | |
| SCHEMBL3821120 | 0.75 | CYP11B2 (0.50) | MKNK1MKNK2SIRT2SIRT1SIRT3 | |
| SCHEMBL28776945 | 0.75 | PARP1 (0.43) | MKNK1MKNK2SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102665718-A | Heterocyclic compounds useful as pdk1 inhibitors | BIOGEN IDEC INC | 2012-09-12 | — | — | CN | disclosed |