Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rosiglitazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 12/20 | 0.98 |
| ▸ | RARG | P13631 | 1/20 | 0.98 |
| ▸ | RXRA | P19793 | 1/20 | 0.98 |
| ▸ | PPARA | Q07869 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rosiglitazone SCHEMBL122053 | 0.99 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL19469505 | 0.99 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL29376790 | 0.99 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL466397 | 0.99 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL5556077 | 0.99 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL5734118 | 0.99 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL504723 | 0.99 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL19023 | 0.99 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL29757195 | 0.99 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL3629161 | 0.98 | PPARG (0.98) | PPARGRARGRXRAPPARAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010067136-A1 | NOVEL CRYSTALLINE FORMS | RICHTER GEDEON NYRT. (HU) | 2010-06-17 | — | — | WO | claimed |
| CN-101203223-A | Pharmaceutical composition comprising amorphous rosiglitazone | SMITHKLINE BEECHAM CORP (US) | 2008-06-18 | — | — | CN | claimed |
| EP-1853262-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AMORPHOUS ROSIGLITAZONE | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-14 | — | — | EP | claimed |
| WO-2006090150-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AMORPHOUS ROSIGLITAZONE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-31 | — | — | WO | claimed |
| US-20060083784-A1 | Amorphous pharmaceutical compositions | SMITHKLINE BEECHAM CORPORATION | 2006-04-20 | — | — | US | claimed |
| WO-2010067136-A1 | NOVEL CRYSTALLINE FORMS | RICHTER GEDEON NYRT. (HU) | 2010-06-17 | — | — | WO | disclosed |
| CN-101203223-A | Pharmaceutical composition comprising amorphous rosiglitazone | SMITHKLINE BEECHAM CORP (US) | 2008-06-18 | — | — | CN | disclosed |
| EP-1853262-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AMORPHOUS ROSIGLITAZONE | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006090150-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AMORPHOUS ROSIGLITAZONE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-31 | — | — | WO | disclosed |
| US-20060083784-A1 | Amorphous pharmaceutical compositions | SMITHKLINE BEECHAM CORPORATION | 2006-04-20 | — | — | US | disclosed |
| EP-1475378-A1 | Antidiabetic thiazolidinedione potassium salt | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2004-11-10 | — | — | EP | disclosed |
| EP-1242418-B1 | ANTIDIABETIC THIAZOLIDINEDIONES AND THEIR PREPARATION | RICHTER GEDEON VEGYESZET (HU) | 2004-10-27 | — | — | EP | disclosed |
| EP-1242418-A1 | ANTIDIABETIC THIAZOLIDINEDIONES AND THEIR PREPARATION | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001044240-A1 | ANTIDIABETIC THIAZOLIDINEDIONES AND THEIR PREPARATION | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2001-06-21 | — | — | WO | disclosed |