Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348326 | 1.00 | TGFBR1 (0.47) | TGFBR1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL3354036 | 0.91 | TGFBR1 (0.53) | TGFBR1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL3354040 | 0.91 | TGFBR1 (0.53) | TGFBR1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL3354077 | 0.91 | TGFBR1 (0.53) | TGFBR1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL3354080 | 0.91 | TGFBR1 (0.53) | TGFBR1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL3349073 | 0.87 | TGFBR1 (0.49) | TGFBR1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL3349068 | 0.87 | TGFBR1 (0.49) | TGFBR1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL3351585 | 0.87 | TGFBR1 (0.52) | TGFBR1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL3351589 | 0.87 | TGFBR1 (0.52) | TGFBR1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL3356857 | 0.87 | TGFBR1 (0.54) | TGFBR1POLBALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723523-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-05-25 | — | — | US | disclosed |
| EP-1753512-B1 | TETRAHYDROPYRIDOTHIOPHENES | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| US-20070244112-A1 | Novel tetrahydropyridothiophenes | ALTANA PHARMA AG (DE) | 2007-10-18 | — | — | US | disclosed |
| EP-1753512-A2 | TETRAHYDROPYRIDOTHIOPHENES | Altana Pharma AG (DE) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005118071-A2 | TETRAHYDROPYRIDOTHIOPHENES | ALTANA PHARMA AG (DE) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244112-A1 | Novel tetrahydropyridothiophenes | BAX, BCL2, BAD | TGFBR1 1294/4885POLB 2428/4885ALDH1A1 683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.