Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | NNMT | P40261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348507 | 1.00 | POLB (0.40) | POLBTDP1RAB9ANPC1NNMT | |
| SCHEMBL3348511 | 1.00 | POLB (0.40) | POLBTDP1RAB9ANPC1NNMT | |
| SCHEMBL1313703 | 0.85 | SMN1; SMN2 (0.38) | POLBTDP1RAB9ANPC1NNMT | |
| SCHEMBL1313705 | 0.82 | POLB (0.36) | POLBTDP1RAB9ANPC1NNMT | |
| SCHEMBL335175 | 0.81 | AR (0.35) | POLBTDP1RAB9ANPC1NNMT | |
| SCHEMBL1313707 | 0.78 | POLB (0.39) | POLBTDP1RAB9ANPC1NNMT | |
| SCHEMBL3330314 | 0.76 | ATM (0.39) | POLBTDP1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3330309 | 0.76 | ATM (0.39) | POLBTDP1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL30884726 | 0.76 | PARP2 (0.46) | POLBTDP1NNMTSMN1; SMN2HPGD | |
| SCHEMBL336655 | 0.74 | L3MBTL1 (0.41) | POLBTDP1RAB9ANPC1NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043714-A1 | TRICYCLIC NITROGEN COMPOUNDS USED AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |