SCHEMBL3350076

SCHEMBL3350076

[CH2]C(N)c1ccc(OC)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C19 P33261 1/20 0.53
CA1 P00915 3/20 0.52
CA2 P00918 3/20 0.52
CA7 P43166 2/20 0.52
CA9 Q16790 2/20 0.52
CA12 O43570 1/20 0.52
CA14 Q9ULX7 1/20 0.52
TDP1 Q9NUW8 3/20 0.48
MAPK1 P28482 2/20 0.48
ALDH1A1 P00352 2/20 0.48
TSHR P16473 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
SLC6A4 P31645 1/20 0.47
CYP3A4 P08684 1/20 0.46
AOC3 Q16853 3/20 0.46
SLC2A1 P11166 1/20 0.45
ACHE P22303 2/20 0.44
MAOA P21397 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6446439 0.80 CA1 (0.58) CYP1A2CYP2D6CYP2C19CA1CA2
SCHEMBL1900477 0.80 CA1 (0.58) CYP1A2CYP2D6CYP2C19CA1CA2
SCHEMBL1305495 0.80 CA1 (0.58) CYP1A2CYP2D6CYP2C19CA1CA2
SCHEMBL114318 0.80 CA1 (0.58) CYP1A2CYP2D6CYP2C19CA1CA2
SCHEMBL11475903 0.80 CA1 (0.58) CYP1A2CYP2D6CYP2C19CA1CA2
SCHEMBL591062 0.80 CA1 (0.58) CYP1A2CYP2D6CYP2C19CA1CA2
SCHEMBL1900910 0.80 CA1 (0.58) CYP1A2CYP2D6CYP2C19CA1CA2
SCHEMBL120603 0.78 CYP1A2 (0.55) CYP1A2CYP2D6CYP2C19CA1CA2
SCHEMBL6023939 0.78 CA1 (0.55) CYP1A2CYP2D6CYP2C19CA1CA2
SCHEMBL56478 0.78 CYP1A2 (0.55) CYP1A2CYP2D6CYP2C19CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104382924-B N6 substituted adenosines derivative and N6 substituted adenines derivatives and application thereof 中国医学科学院药物研究所 2017-12-22 CN disclosed
WO-2010046808-A2 A PROCESS FOR THE PREPARATION OF VENLAFAXINE HYDROCHLORIDE ALEMBIC LIMITED (IN) 2010-04-29 WO disclosed
WO-2006067808-A1 AN IMPROVED PROCESS FOR PRODUCTION OF INTERMEDIATE OF ANTIDEPRESSANT AGENT CALYX CHEMICALS & PHARMACEUTICALS PRIVATE LIMITED (IN) 2006-06-29 WO disclosed
EP-1135358-A1 DERIVATIVES OF (+)-VENLAFAXINE AND METHODS OF PREPARING AND USING THE SAME Sepracor Inc. (US) 2001-09-26 EP disclosed
WO-2000032555-A1 DERIVATIVES OF (+)-VENLAFAXINE AND METHODS OF PREPARING AND USING THE SAME SEPRACOR INC. (US) 2000-06-08 WO disclosed