Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.54 |
| ▸ | HTR2B | P41595 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 9/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348321 | 0.74 | HTR2C (0.52) | HTR2CHTR2BSLC6A4ALDH1A1KMT2A | |
| SCHEMBL10361712 | 0.72 | HTR2C (0.51) | HTR2CHTR2BHTR2ASLC6A4KCNH2 | |
| SCHEMBL2282000 | 0.70 | HTR2C (1.00) | HTR2CHTR2BSLC6A4 | |
| SCHEMBL2282006 | 0.70 | HTR2C (1.00) | HTR2CHTR2BSLC6A4 | |
| SCHEMBL24252977 | 0.69 | HTR2C (0.48) | HTR2CHTR2BHTR2ASLC6A4KCNH2 | |
| SCHEMBL5989716 | 0.69 | HTR2C (0.48) | HTR2CHTR2BHTR2ASLC6A4KCNH2 | |
| SCHEMBL7182380 | 0.69 | TTR (0.58) | HTR2CHTR2BHTR2ASLC6A4KCNH2 | |
| SCHEMBL30451605 | 0.69 | HTR2C (0.48) | HTR2CHTR2BHTR2ASLC6A4KCNH2 | |
| SCHEMBL2551468 | 0.69 | MAPT (0.56) | HTR2CHTR2BHTR2ASLC6A4KCNH2 | |
| SCHEMBL19563733 | 0.69 | EPAS1 (0.49) | HTR2CHTR2BHTR2ASLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059393-A1 | SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-27 | — | — | WO | claimed |