Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 5/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 3/20 | 0.38 |
| ▸ | PRCP | P42785 | 2/20 | 0.38 |
| ▸ | MC5R | P33032 | 2/20 | 0.38 |
| ▸ | MC3R | P41968 | 2/20 | 0.38 |
| ▸ | MC1R | Q01726 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3349710 | 0.90 | KCNQ3 (0.46) | KCNH2GAAHPGDSMN1; SMN2 | |
| SCHEMBL3380842 | 0.88 | KCNH2 (0.40) | KCNH2SMN1; SMN2KITPTGER4PTGER2 | |
| SCHEMBL3346567 | 0.86 | KCNH2 (0.59) | KCNH2PRCPMAPK1KMT2A | |
| SCHEMBL3350804 | 0.85 | MAPK1 (0.41) | KCNH2KITMAPK1 | |
| SCHEMBL13365050 | 0.84 | SSTR4 (0.39) | KCNH2SMN1; SMN2MC4RMAPK1 | |
| SCHEMBL13364977 | 0.84 | KCNH2 (0.60) | KCNH2GAAHPGDSMN1; SMN2MC4R | |
| SCHEMBL3347919 | 0.84 | KCNH2 (0.60) | KCNH2GAAHPGDSMN1; SMN2MC4R | |
| SCHEMBL13365057 | 0.83 | KCNH2 (0.38) | KCNH2GAAHPGDSMN1; SMN2KIT | |
| SCHEMBL3353143 | 0.82 | KCNH2 (0.53) | KCNH2GAAHPGDSMN1; SMN2MC4R | |
| SCHEMBL13365101 | 0.81 | KCNH2 (0.54) | KCNH2GAAHPGDSMN1; SMN2MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |