Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 11/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 2/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13365057 | 0.92 | KCNH2 (0.38) | MAPK1KCNH2KITROCK2S1PR2 | |
| SCHEMBL3380842 | 0.91 | KCNH2 (0.40) | MAPK1KCNH2KITROCK2ROCK1 | |
| SCHEMBL3349710 | 0.91 | KCNQ3 (0.46) | KCNH2NTSR1 | |
| SCHEMBL3346689 | 0.90 | POLB (0.50) | KITROCK2ROCK1 | |
| SCHEMBL3346383 | 0.89 | KCNH2 (0.50) | MAPK1KCNH2KITROCK2ROCK1 | |
| SCHEMBL3350882 | 0.85 | KCNH2 (0.46) | MAPK1KCNH2KIT | |
| SCHEMBL3348168 | 0.83 | KCNH2 (0.45) | MAPK1KCNH2KITROCK2MAPK3 | |
| SCHEMBL3346544 | 0.82 | TRPM5 (0.38) | MAPK1KCNH2ROCK2 | |
| SCHEMBL3346446 | 0.82 | ROCK2 (0.42) | MAPK1KCNH2ROCK2S1PR3 | |
| SCHEMBL13365050 | 0.81 | SSTR4 (0.39) | MAPK1KCNH2ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |