Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14158351 | 0.84 | PDE10A (0.54) | PDE10AMAPTALDH1A1NPC1MEN1 | |
| SCHEMBL3346532 | 0.77 | CDK2 (0.38) | PDE10AMAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL5454734 | 0.77 | PDE10A (0.53) | PDE10AMAPTKDM4ESMN1; SMN2POLB | |
| SCHEMBL12952984 | 0.73 | PDE10A (0.53) | PDE10ALMNAHSD17B10KCNN3KCNN1 | |
| SCHEMBL5460421 | 0.72 | PDE10A (0.59) | PDE10AMAPTKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL312516 | 0.72 | PDE10A (0.64) | PDE10AMAPTKDM4ERAB9AALDH1A1 | |
| SCHEMBL30579493 | 0.71 | PDE10A (0.50) | PDE10AKCNN3KCNN1KCNN2CDK2 | |
| SCHEMBL20557853 | 0.71 | PDE10A (0.50) | PDE10AKCNN3KCNN1KCNN2CDK2 | |
| SCHEMBL1018372 | 0.71 | PDE10A (0.67) | PDE10AKCNN3KCNN1KCNN2CDK2 | |
| SCHEMBL5468136 | 0.71 | PDE10A (0.53) | PDE10ACASP3SENP8SENP7SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |