Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902940 | 0.87 | PDE10A (0.35) | CDK2PDE10ACCNE1CCNT1CDK9 | |
| SCHEMBL3346499 | 0.79 | CDK2 (0.35) | CDK2PDE10ACCNE1CCNT1CDK9 | |
| SCHEMBL3346746 | 0.78 | KCNN1 (0.38) | CDK2KDM4ERXFP1ALDH1A1PDE10A | |
| SCHEMBL3351283 | 0.77 | PDE10A (0.53) | CDK2RAB9ASMN1; SMN2NPC1ALOX12 | |
| SCHEMBL3351751 | 0.76 | CDK2 (0.38) | CDK2PDE10ACCNE1CCNT1CDK9 | |
| SCHEMBL3347648 | 0.76 | GRM5 (0.33) | CDK2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL3351298 | 0.76 | GRM5 (0.33) | — | |
| SCHEMBL3346510 | 0.76 | GRM5 (0.37) | PDE10A | |
| SCHEMBL3345946 | 0.76 | GRM5 (0.39) | CDK2RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL3347209 | 0.76 | KCNN3 (0.36) | CDK2PDE10ACCNE1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |