Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.43 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353468 | 0.97 | MKNK1 (0.42) | MKNK1MKNK2F2RL1HDAC6HDAC8 | |
| SCHEMBL197529 | 0.95 | MKNK1 (0.40) | MKNK1MKNK2F2RL1HDAC6HDAC8 | |
| SCHEMBL3351854 | 0.89 | HDAC4 (0.41) | MKNK1MKNK2HDAC6HDAC8HDAC4 | |
| SCHEMBL3356523 | 0.88 | HDAC1 (0.44) | F2RL1HDAC6HDAC8HDAC4HDAC1 | |
| SCHEMBL3354030 | 0.86 | HDAC4 (0.40) | MKNK1MKNK2HDAC6HDAC8HDAC4 | |
| SCHEMBL3358736 | 0.85 | HDAC1 (0.43) | F2RL1HDAC6HDAC8HDAC4HDAC1 | |
| SCHEMBL3352449 | 0.85 | HDAC1 (0.41) | HDAC6HDAC8HDAC4HDAC1HDAC7 | |
| SCHEMBL3351547 | 0.85 | ALDH1A1 (0.41) | HDAC6HDAC8HDAC4HDAC1HDAC7 | |
| SCHEMBL658769 | 0.85 | MKNK1 (0.46) | MKNK1MKNK2F2RL1HDAC1ALDH1A1 | |
| SCHEMBL197320 | 0.84 | HDAC4 (0.39) | MKNK1MKNK2HDAC6HDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198299-B2 | Cycloalkylidene and heterocycloalkylidene inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-06-12 | — | — | US | claimed |
| US-20100022543-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-01-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022543-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC2 | MKNK1 714/4885MKNK2 539/4885F2RL1 2461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.