SCHEMBL33530380

SCHEMBL33530380

CN1CCN(c2ccc(C(=O)O)c(Oc3cnc4[nH]ccc4c3)c2)CC1

nearest known ligand 0.54

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
BCL2A1 Q16548 4/20 0.54
BID P55957 3/20 0.53
MCL1 Q07820 2/20 0.53
BCL2 P10415 13/20 0.49
BCL2L1 Q07817 3/20 0.49
BAD Q92934 1/20 0.40
ABL1 P00519 1/20 0.40
BRD4 O60885 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12067449 1.00 BCL2A1 (0.54) BCL2A1BIDMCL1BCL2BCL2L1
SCHEMBL19867786 0.91 BCL2 (0.50) BCL2A1BIDMCL1BCL2BCL2L1
SCHEMBL20082257 0.90 BCL2A1 (0.51) BCL2A1BIDMCL1BCL2BCL2L1
SCHEMBL18214247 0.89 BCL2A1 (0.50) BCL2A1BIDMCL1BCL2BCL2L1
SCHEMBL19774754 0.88 BCL2A1 (0.54) BCL2A1BIDMCL1BCL2BCL2L1
SCHEMBL19692632 0.86 BCL2 (0.54) BCL2A1BIDMCL1BCL2BCL2L1
SCHEMBL25243081 0.85 BCL2 (0.48) BCL2A1BIDMCL1BCL2BCL2L1
SCHEMBL31321339 0.84 BCL2 (0.55) BCL2A1BIDMCL1BCL2BCL2L1
SCHEMBL24775466 0.84 BCL2 (0.55) BCL2A1BIDMCL1BCL2BCL2L1
SCHEMBL28839728 0.84 BCL2 (0.51) BCL2A1BIDMCL1BCL2BCL2L1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260092057-A1 BCL-XL/BCL-2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092057-A1 BCL-XL/BCL-2 DEGRADERS AND USES THEREOF BCL2L2, BCL2A1, BCL2L1 BCL2A1 2/4885BID 17/4885MCL1 12/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.