SCHEMBL33530594

SCHEMBL33530594

COc1cc(-c2cn(C)c(=O)c(C)c2C)cc(OC)c1CN(C)C(=O)OC(C)(C)C

nearest known ligand 0.69

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
BRD9 Q9H8M2 18/20 0.69
BRD4 O60885 15/20 0.69
BRD7 Q9NPI1 11/20 0.69
BRD2 P25440 6/20 0.69
TAF1 P21675 1/20 0.45
TGFBR1 P36897 1/20 0.45
BRPF1 P55201 1/20 0.45
ACVR1 Q04771 1/20 0.45
BPTF Q12830 1/20 0.45
TAF1L Q8IZX4 1/20 0.45
CREBBP Q92793 1/20 0.45
CECR2 Q9BXF3 1/20 0.45
BAZ2B Q9UIF8 1/20 0.45
ATAD2B Q9ULI0 1/20 0.45
CD274 Q9NZQ7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23575596 0.84 BRD9 (0.49) BRD9BRD4BRD7BRD2TAF1
SCHEMBL19869765 0.82 BRD9 (1.00) BRD9BRD4BRD7BRD2TAF1
SCHEMBL33531763 0.80 BRD9 (0.67) BRD9BRD4BRD7BRD2TAF1
SCHEMBL23575321 0.77 BRD9 (0.45) BRD9BRD4BRD7BRD2TAF1
SCHEMBL33532865 0.77 BRD9 (0.72) BRD9BRD4BRD7BRD2TAF1
SCHEMBL26353762 0.77 CACNA1G (0.38) BRD9BRD4BRD7BRD2CD274
SCHEMBL23783038 0.76 BRD4 (0.53) BRD9BRD4BRD7BRD2CD274
SCHEMBL33533083 0.75 BRD9 (0.51) BRD9BRD4BRD7BRD2TAF1
SCHEMBL19869768 0.75 BRD9 (0.72) BRD9BRD4BRD7BRD2TAF1
SCHEMBL33532986 0.74 BRD4 (0.50) BRD9BRD4BRD7BRD2TAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260092061-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION AMPHISTA THERAPEUTICS LTD (GB) 2026-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092061-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION BCL9L, RBBP9, BRD9 BRD9 3/4885BRD4 161/4885BRD7 18/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.