Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 18/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358957 | 0.92 | TRPV1 (0.65) | TRPV1CYP3A4CYP2D6CCNE1CDK2 | |
| SCHEMBL3354668 | 0.86 | TRPV1 (0.60) | TRPV1CYP3A4CYP2D6 | |
| SCHEMBL2319982 | 0.81 | TRPV1 (0.68) | TRPV1CYP3A4CYP2D6CCNE1CDK2 | |
| SCHEMBL2320518 | 0.78 | TRPV1 (1.00) | TRPV1CYP3A4CYP2D6 | |
| SCHEMBL2319990 | 0.78 | TRPV1 (1.00) | TRPV1CYP3A4CYP2D6 | |
| SCHEMBL616146 | 0.77 | TRPV1 (0.76) | TRPV1CYP3A4CYP2D6CCNE1CDK2 | |
| SCHEMBL15446074 | 0.77 | TRPV1 (0.76) | TRPV1CYP3A4CYP2D6CCNE1CDK2 | |
| Hydrochloric Acid SCHEMBL3765639 | 0.76 | TRPV1 (0.75) | TRPV1CYP3A4CYP2D6CCNE1CDK2 | |
| SCHEMBL620089 | 0.76 | TRPV1 (0.74) | TRPV1CYP3A4CYP2D6CCNE1CDK2 | |
| Sulfuric Acid SCHEMBL3765635 | 0.74 | TRPV1 (0.71) | TRPV1CYP3A4CYP2D6CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010023512-A1 | NOVEL VANILLOID RECEPTOR MODULATORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MATRIX LABORATORIES LTD. (IN) | 2010-03-04 | — | — | WO | claimed |
| WO-2010023512-A1 | NOVEL VANILLOID RECEPTOR MODULATORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MATRIX LABORATORIES LTD. (IN) | 2010-03-04 | — | — | WO | disclosed |