Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 6/20 | 0.98 |
| ▸ | RORC | P51449 | 5/20 | 0.98 |
| ▸ | OSBP2 | Q969R2 | 3/20 | 0.98 |
| ▸ | USP2 | O75604 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.98 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.98 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.83 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.83 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.82 |
| ▸ | CRYAB | P02511 | 1/20 | 0.79 |
| ▸ | HMGCR | P04035 | 1/20 | 0.79 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.79 |
| ▸ | ITGAV | P06756 | 1/20 | 0.79 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.79 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.79 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.78 |
| ▸ | DHCR24 | Q15392 | 1/20 | 0.76 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.74 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL21707472 | 0.99 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL21447271 | 0.99 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL21340667 | 0.99 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL23761109 | 0.99 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL22225160 | 0.99 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL23579652 | 0.99 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL21539517 | 0.99 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL23365796 | 0.99 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL22095727 | 0.99 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL21445079 | 0.99 | OSBP (1.00) | OSBPRORCOSBP2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135971-A | Carbon-losing cholestanal, and preparation method and application thereof | 成都贝诺科成生物科技有限公司 | 2021-07-20 | — | — | CN | claimed |
| US-9427431-B2 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2016-08-30 | — | — | US | disclosed |
| EP-1067939-B1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG PROTEIN SIGNALING PATHWAYS | UNIV JOHNS HOPKINS (US) | 2015-09-16 | — | — | EP | disclosed |
| US-20120183603-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | BEACHY PHILIP A (US) | 2012-07-19 | — | — | US | disclosed |
| US-8097632-B2 | Blocking hedgehog protein transduction signal passageway using alkaloid steroid | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2012-01-17 | — | — | US | disclosed |
| US-20100273818-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2010-10-28 | — | — | US | disclosed |
| US-20080058298-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2008-03-06 | — | — | US | disclosed |
| US-7291626-B1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2007-11-06 | — | — | US | disclosed |
| US-20060142245-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2006-06-29 | — | — | US | disclosed |
| US-6867216-B1 | Inhibitors of hedgehog signal pathways, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2005-03-15 | — | — | US | disclosed |
| US-20020034725-A1 | SENSITIZATION OF CELLS TO RADIATION AND AND CHEMOTHERAPY | NATIONAL INSTITUTES OF HEALTH, THE | 2002-03-21 | — | — | US | disclosed |
| US-20020006931-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | THE JOHNS HOPKINS UNIVERSITY | 2002-01-17 | — | — | US | disclosed |
| EP-1067939-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | The Johns Hopkins University, School of Medicine, Office of Technology Licencing (US) | 2001-01-17 | — | — | EP | disclosed |
| EP-0910385-A4 | SENSITIZATION OF CELLS TO RADIATION AND CHEMOTHERAPY | UNIV PENNSYLVANIA (US) | 1999-12-22 | — | — | EP | disclosed |
| WO-1999052534-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-10-21 | — | — | WO | disclosed |
| EP-0910385-A1 | SENSITIZATION OF CELLS TO RADIATION AND CHEMOTHERAPY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1999-04-28 | — | — | EP | disclosed |
| US-5792657-A | Steroid secreting human adrenocortical carcinoma cell lines | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1997038697-A1 | SENSITIZATION OF CELLS TO RADIATION AND CHEMOTHERAPY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1997-10-23 | — | — | WO | disclosed |
| EP-0527757-A1 | COMPOSITION AND METHODS FOR TREATMENT OF ACNE VULGARIS AND RETARDATION OF AGEING. | LEUNG LIT HUNG (HK) | 1993-02-24 | — | — | EP | disclosed |
| WO-1991014431-A1 | COMPOSITION AND METHODS FOR TREATMENT OF ACNE VULGARIS AND RETARDATION OF AGEING | LEUNG LIT HUNG (HK) | 1991-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120183603-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | SHH, GLI1, SMO | OSBP 643/4885RORC 487/4885OSBP2 911/4885 |
| US-20100273818-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | SHH, GLI1, SMO | OSBP 643/4885RORC 487/4885OSBP2 911/4885 |
| US-20020006931-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | SHH, SMO, GLI1 | OSBP 542/4885RORC 444/4885OSBP2 591/4885 |
| US-20080058298-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | SHH, GLI1, SMO | OSBP 551/4885RORC 484/4885OSBP2 753/4885 |
| US-20060142245-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | SHH, GLI1, SMO | OSBP 643/4885RORC 487/4885OSBP2 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.