Cholesterol

Cholesterol

SCHEMBL21340667

CC(C)CCC[C@H](C)[C@@H]1CC[C@@H]2[C@H]3CC=C4C[C@H](O)CC[C@@]4(C)[C@@H]3CC[C@]21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OSBP P22059 6/20 1.00
RORC P51449 5/20 1.00
OSBP2 Q969R2 3/20 1.00
USP2 O75604 1/20 1.00
LMNA P02545 1/20 1.00
ABCB1 P08183 1/20 1.00
CYP46A1 Q9Y6A2 1/20 1.00
GRIN1 Q05586 6/20 0.85
GRIN2A Q12879 6/20 0.85
NR1H3 Q13133 7/20 0.84
CRYAB P02511 1/20 0.80
HMGCR P04035 1/20 0.80
ITGB3 P05106 1/20 0.80
ITGAV P06756 1/20 0.80
SREBF2 Q12772 1/20 0.80
NPC1L1 Q9UHC9 1/20 0.80
GRIN2B Q13224 5/20 0.80
DHCR24 Q15392 1/20 0.77
EPHA2 P29317 1/20 0.75
NR1H2 P55055 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cholesterol SCHEMBL21707472 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL21539517 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL22095727 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL21447271 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL23579652 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL23365796 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL21650234 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL23761109 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL21445079 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA
Cholesterol SCHEMBL20607477 1.00 OSBP (1.00) OSBPRORCOSBP2USP2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12569501-B2 Neurosteroids and enantiomers thereof for the prevention and treatment of neurodegenerative conditions WASHINGTON UNIVERSITY (US) 2026-03-10 US claimed
US-20240041898-A9 NEUROSTEROIDS AND ENANTIOMERS THEREOF FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE CONDITIONS WASHINGTON UNIVERSITY 2024-02-08 US claimed
US-20230058339-A1 NEUROSTEROIDS AND ENANTIOMERS THEREOF FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE CONDITIONS WASHINGTON UNIVERSITY ST LOUIS 2023-02-23 US claimed
US-20230043677-A1 INHALABLE THERAPEUTICS OREGON STATE UNIVERSITY (US) 2023-02-09 US claimed
WO-2026098601-A1 LIPID NANOPARTICLE FOR DELIVERING LOAD 北京剂泰生命科技有限公司 2026-05-15 WO disclosed
US-20260124157-A1 METHODS OF SELF-AMPLIFYING RNA-LIPID NANOPARTICLE MANUFACTURE AND COMPOSITIONS DERIVED THEREFROM GENVAX TECH INC (US) 2026-05-07 US disclosed
EP-4683905-A1 IONIZABLE ANIONIC LIPIDS Nanovation Therapeutics Inc. (CA) 2026-01-28 EP disclosed
EP-4676446-A1 NOVEL LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS CureVac SE (DE) 2026-01-14 EP disclosed
US-12458604-B2 Methods of lipid nanoparticle manufacture and compositions derived therefrom THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2025-11-04 US disclosed
WO-2025213271-A1 METHOD OF DELIVERING NUCLEIC ACID TO MACROPHAGES AND/OR MONOCYTES AND COMPOSITIONS FOR USE THEREOF NANOVATION THERAPEUTICS INC. (CA) 2025-10-16 WO disclosed
WO-2025213270-A1 METHOD OF DELIVERING NUCLEIC ACID TO T CELLS AND COMPOSITIONS FOR USE THEREOF NANOVATION THERAPEUTICS INC. (CA) 2025-10-16 WO disclosed
EP-4630061-A1 LIPID NANOPARTICLES COMPRISING ELEVATED NEUTRAL LIPID AND A TARGETING MOIETY FOR TARGETED DELIVERY OF NUCLEIC ACID Nanovation Therapeutics Inc. (CA) 2025-10-15 EP disclosed
WO-2022140404-A1 ZWITTERIONIC LIPID NANOPARTICLE COMPOSITIONS, AND METHODS OF USE CORNELL UNIVERSITY (US) 2022-06-30 WO disclosed
EP-3539031-B1 SKIN PERMEABILITY PREDICTION ERCO PHARMA AB (SE) 2022-06-29 EP disclosed
EP-3997117-A1 COMPOSITIONS AND METHODS FOR ENHANCING CELL CULTURE Life Technologies Corporation (US) 2022-05-18 EP disclosed
WO-2022081752-A1 METHODS OF LIPID NANOPARTICLE MANUFACTURE AND COMPOSTIONS DERIVED THEREFROM George Mason Research Foundation, Inc. (US) 2022-04-21 WO disclosed
CN-114222813-A Compositions and methods for enhancing cell culture 生命技术公司 2022-03-22 CN disclosed
WO-2022040641-A2 FUNCTIONAL IONIZABLE PHOSPHOLIPIDS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-02-24 WO disclosed
US-20190307690-A1 Liposomal Delivery Systems for Oxaliplatin and in Dual Drug Delivery in Combination with Chemo-sensitizing and Chemo-therapeutic agents THE AMERICAN UNIVERSITY IN CAIRO 2019-10-10 US disclosed
US-20190279743-A1 SKIN PERMEABILITY PREDICTION ERCO PHARMA AB (SE) 2019-09-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12569501-B2 Neurosteroids and enantiomers thereof for the prevention and treatment of neurodegenerative conditions ATG13, GSK3B, HSD11B1 OSBP 966/4885RORC 393/4885OSBP2 1193/4885
US-12458604-B2 Methods of lipid nanoparticle manufacture and compositions derived therefrom RNMT, HNRNPM, AUP1 OSBP 526/4885RORC 840/4885OSBP2 289/4885
US-20260124157-A1 METHODS OF SELF-AMPLIFYING RNA-LIPID NANOPARTICLE MANUFACTURE AND COMPOSITIONS DERIVED THEREFROM HNRNPM, SARNP, SNRPF OSBP 732/4885RORC 2721/4885OSBP2 1039/4885
US-20230043677-A1 INHALABLE THERAPEUTICS RNMT, CETP, NPC1L1 OSBP 618/4885RORC 171/4885OSBP2 459/4885
US-20190307690-A1 Liposomal Delivery Systems for Oxaliplatin and in Dual Drug Delivery in Combination with Chemo-sensitizing and Chemo-therapeutic agents TTPA, SLC5A6, CACNG6 OSBP 178/4885RORC 3080/4885OSBP2 236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.