SCHEMBL3355940

SCHEMBL3355940

O=C(C(CCl)c1ccccc1)C(CCl)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.47
EPHX1 P07099 1/20 0.47
LMNA P02545 4/20 0.46
HSD17B10 Q99714 1/20 0.46
KCNQ2 O43526 1/20 0.45
CYP2D6 P10635 1/20 0.44
SRC P12931 1/20 0.44
MAPK1 P28482 2/20 0.43
ALDH1A1 P00352 2/20 0.42
KDM4E B2RXH2 1/20 0.42
GAA P10253 1/20 0.42
POLB P06746 1/20 0.42
TRPA1 O75762 1/20 0.41
GSK3B P49841 1/20 0.41
HIF1A Q16665 1/20 0.41
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL305061 0.86 CYP2C19 (0.57) CYP2C19EPHX1LMNACYP2D6SRC
SCHEMBL7255213 0.84 CYP2C19 (0.46) CYP2C19EPHX1LMNAHSD17B10KCNQ2
SCHEMBL27633580 0.83 SRD5A2 (0.50)
SCHEMBL11637533 0.83 CYP2C19 (0.44) CYP2C19EPHX1LMNAHSD17B10KCNQ2
SCHEMBL4436342 0.83 CYP2C19 (0.44) CYP2C19EPHX1LMNAHSD17B10KCNQ2
SCHEMBL2003969 0.83 CYP2C19 (0.44) CYP2C19EPHX1LMNAHSD17B10KCNQ2
SCHEMBL8550655 0.81 SMN1; SMN2 (0.54) KDM4EGAA
SCHEMBL27586579 0.80 ESR1 (0.48) CYP2C19LMNAHSD17B10CYP2D6SRC
SCHEMBL27743457 0.80 CYP2C9 (0.45) CYP2C19LMNAHSD17B10CYP2D6POLB
SCHEMBL4935067 0.79 LMNA (0.61) LMNAHSD17B10KCNQ2ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4059610-A Process for preparing isocyanic acid derivatives KAO SOAP CO., LTD. (JA) 1977-11-22 US claimed
CN-108794333-A The method for preparing cinnamic acid benzoyl first ester type compound 湖北固润科技股份有限公司 2018-11-13 CN disclosed
CN-1854135-B Heteronuclear compound with dicyandiamide connection and its medicinal use LI WEIZHANG 2013-06-12 CN disclosed
EP-2161272-A1 Phenanthrolines BASF SE (DE) 2010-03-10 EP disclosed
CN-1854135-A Heteronuclear compound with dicyandiamide connection and its medicinal use LI WEIZHANG (CN) 2006-11-01 CN disclosed
CN-1329648-A Material consisting of cyanoacrylate and aldehyde-or ketone-condensation products for adhesives, coatings and sealants HENKEL KGAA (DE) 2002-01-02 CN disclosed
US-4059610-A Process for preparing isocyanic acid derivatives KAO SOAP CO., LTD. (JA) 1977-11-22 US disclosed