Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385162 | 0.85 | IKBKB (0.47) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL4893442 | 0.83 | HRH3 (0.48) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL28696935 | 0.79 | KDM4E (0.52) | KDM4ERAB9ANPC1PDGFRBPDGFRA | |
| SCHEMBL3355241 | 0.74 | IKBKB (0.49) | PDGFRBPDGFRACA2 | |
| SCHEMBL28691325 | 0.72 | KDM4E (0.51) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL28704770 | 0.71 | ATP4A (0.46) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL2702407 | 0.71 | GSK3B (0.56) | CA2GSK3BCDK5 | |
| SCHEMBL2702040 | 0.70 | IKBKB (0.49) | KDM4ERAB9ANPC1PDGFRBPDGFRA | |
| SCHEMBL28684481 | 0.70 | CYP19A1 (0.49) | KDM4EALDH1A1RAB9ANPC1LMNA | |
| SCHEMBL9326916 | 0.70 | KMT2A (0.44) | KDM4EALDH1A1LMNAL3MBTL1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891049-B1 | METHOD FOR PRODUCING 2-(2-AMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | SANOFI SA (FR) | 2017-07-19 | — | — | EP | disclosed |
| EP-2226319-B1 | Process for the preparation of 2-(2-aminopyrimidin-4-yl)-1H-indol-5-carbonic acid derivatives | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |
| EP-2226319-A1 | Process for the preparation of 2-(2-Amino-pyrimidin-4-yl)-1H-indol-5-carbonic acid derivatives | sanofi-aventis (FR) | 2010-09-08 | — | — | EP | disclosed |
| EP-1891049-A1 | METHOD FOR PRODUCING 2-(2-AMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | Sanofi-Aventis (FR) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128585-A1 | METHOD FOR PRODUCING 2-(2-AMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | SANOFI-AVENTIS (DE) | 2006-12-07 | — | — | WO | disclosed |