N,N-Dimethyltryptamine

N,N-Dimethyltryptamine

SCHEMBL335710

CN(C)CCc1c[nH]c2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 9/20 1.00
HTR1A P08908 8/20 1.00
HTR2C P28335 7/20 1.00
HTR2B P41595 5/20 1.00
SLC6A4 P31645 3/20 0.81
HTR6 P50406 6/20 0.76
HTR1B P28222 4/20 0.76
HTR7 P34969 3/20 0.76
HTR5A P47898 2/20 0.76
ADRA2A P08913 2/20 0.76
ADRA2B P18089 2/20 0.76
ADRA2C P18825 2/20 0.76
ADRA1A P35348 2/20 0.76
HRH1 P35367 2/20 0.76
ADRA1B P35368 2/20 0.76
MAOA P21397 1/20 0.76
ADRA1D P25100 1/20 0.76
CHRNB4 P30926 1/20 0.76
CHRNA3 P32297 1/20 0.76
CYP3A4 P08684 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
N,N-Dimethyltryptamine SCHEMBL29350959 1.00 HTR2A (1.00) HTR2AHTR1AHTR2CHTR2BSLC6A4
N,N-Dimethyltryptamine SCHEMBL27221709 1.00 HTR2A (1.00) HTR2AHTR1AHTR2CHTR2BSLC6A4
N,N-Dimethyltryptamine SCHEMBL23069121 0.98 HTR2A (0.97) HTR2AHTR1AHTR2CHTR2BSLC6A4
N,N-Dimethyltryptamine SCHEMBL25285129 0.98 HTR2A (0.97) HTR2AHTR1AHTR2CHTR2BSLC6A4
N,N-Dimethyltryptamine SCHEMBL27657713 0.91 HTR1A (0.82) HTR2AHTR1AHTR2CHTR2BSLC6A4
SCHEMBL3957606 0.90 SLC6A4 (1.00) HTR2AHTR1AHTR2CHTR2BSLC6A4
SCHEMBL30896267 0.89 HTR2A (0.81) HTR2AHTR1AHTR2CHTR2BSLC6A4
N,N-Dimethyltryptamine SCHEMBL25256369 0.88 HTR2A (0.79) HTR2AHTR1AHTR2CHTR2BSLC6A4
N,N-Dimethyltryptamine SCHEMBL31289392 0.88 HTR1A (0.78) HTR2AHTR1AHTR2CHTR2BSLC6A4
N,N-Dimethyltryptamine SCHEMBL30785193 0.88 HTR1A (0.78) HTR2AHTR1AHTR2CHTR2BSLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3420 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144807-A1 METHOD OF ADMINISTRATION OF A PARENTERAL FORMULATION COMPRISING A PSYCHEDELIC AGENT CYBIN UK LTD (GB) 2026-05-28 US claimed
US-12616706-B2 Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations Arbormentis LLC (US) 2026-05-05 US claimed
US-20260116853-A1 NEW N,N-DIMETHYLTRYPTAMINE SALTS AND CRYSTALLINE SALT FORMS ATAI THERAPEUTICS INC (US) 2026-04-30 US claimed
EP-4728531-A1 BIOADAPTIVE THERAPEUTIC ENVIRONMENTS Therapod LLC (US) 2026-04-22 EP claimed
US-12595497-B2 Processes for the production of tryptamines COMPASS PATHFINDER LIMITED (GB) 2026-04-07 US claimed
US-20260090584-A1 SYSTEMS AND METHODS FOR ESTIMATING AEROSOLIZATION EMISSION SCIENTIFIC HORIZONS CONSULTING LLC (US) 2026-04-02 US claimed
US-20260090957-A1 Process for making aqueous therapeutic particle having stable exterior water clustering with nanosized thickness DRESDNER JR KARL P (US) 2026-04-02 US claimed
US-20260083759-A1 Combinations Comprising Psychedelics for the Treatment of Schizophrenia and Other Neuropsychiatric and Neurologic Disorders HADASIT MED RES SERVICE (IL) 2026-03-26 US claimed
US-20260080800-A1 COMBINATION THERAPY WITH DIGITAL THERAPEUTICS FOR IMPROVED IMMUNE FUNCTION REMEPY HEALTH LTD (IL) 2026-03-19 US claimed
EP-4704826-A1 COMPOSITIONS AND METHODS FOR TREATING POST-TRAUMATIC STRESS DISORDER Yale University (US) 2026-03-11 EP claimed
EP-1319070-A2 MAMMALIAN RECEPTOR GENES AND USES Oregon Health & Science University (US) 2003-06-18 EP claimed
US-20030082802-A1 Preparing culture of nervous system tissues; prepare nutrient broth containing agonist, inoculate with nervous system stem cells, propagate and recover cells PSYCHIATRIC GENOMICS, INC. (US) 2003-05-01 US claimed
US-20030078231-A1 Orthomolecular sulpho-adenosylmethionine derivatives with antioxidant properties WILBURN MICHAEL D (US) 2003-04-24 US claimed
US-20030007961-A1 Orthomolecular vitamin E derivatives WILBURN MICHAEL D (US) 2003-01-09 US claimed
WO-2002102988-A2 METHOD FOR NEURAL STEM CELL DIFFERENTIATION USING 5HT-1A AGONISTS PSYCHIATRIC GENOMICS, INC. (US) 2002-12-27 WO claimed
WO-2002022801-A2 MAMMALIAN RECEPTOR GENES AND USES OREGON HEALTH & SCIENCE UNIVERSITY (US) 2002-03-21 WO claimed
EP-0251938-B1 STEREOSPECIFIC PROCESS FOR THE SYNTHESIS OF INDOLE DERIVATIVES SANOFI (FR) 1991-11-06 EP claimed
EP-0251938-A1 Stereospecific process for the synthesis of indole derivatives SANOFI (FR) 1988-01-07 EP claimed
US-4620977-A Treatment methods, particularly for psychoactive drug dependence STRAHILEVITZ MEIR 1986-11-04 US claimed
US-4375414-A Immunological methods for removing species from the blood circulatory system and devices therefor STRAHILEVITZ MEIR 1983-03-01 US claimed