Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 5/20 | 0.34 |
| ▸ | LCK | P06239 | 4/20 | 0.34 |
| ▸ | BTK | Q06187 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359243 | 0.90 | ZAP70 (0.38) | ZAP70JAK3LCKBTKEGFR | |
| SCHEMBL3362887 | 0.84 | ZAP70 (0.46) | ZAP70TLR7JAK3LCKBTK | |
| SCHEMBL3359058 | 0.83 | ZAP70 (0.42) | ZAP70TLR9JAK3EGFRJAK2 | |
| SCHEMBL3359641 | 0.83 | ZAP70 (0.41) | ZAP70JAK3JAK2PTK2SYK | |
| SCHEMBL1158133 | 0.82 | ZAP70 (0.48) | ZAP70JAK3JAK2SOS1SYK | |
| SCHEMBL3359028 | 0.82 | ZAP70 (0.41) | ZAP70TLR9JAK3LCKBTK | |
| SCHEMBL27826596 | 0.81 | ZAP70 (0.37) | ZAP70TLR7TLR9TLR8CHEK1 | |
| SCHEMBL1046844 | 0.81 | ZAP70 (0.59) | ZAP70TLR7TLR9TLR8JAK2 | |
| SCHEMBL3359055 | 0.81 | ZAP70 (0.40) | ZAP70JAK3JAK2PTK2SYK | |
| SCHEMBL3359747 | 0.79 | ENPP2 (0.44) | ZAP70JAK3BTKEGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |