Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2196381 | 0.87 | GCK (0.41) | GCKMAPTKMT2AHSD17B1HSD17B2 | |
| SCHEMBL2196377 | 0.87 | GCK (0.41) | GCKMAPTKMT2AHSD17B1HSD17B2 | |
| SCHEMBL3356836 | 0.83 | GCK (0.40) | GCKCCR5HSD17B1HSD17B2GAA | |
| SCHEMBL1711778 | 0.83 | GCK (0.40) | GCKCCR5HSD17B1HSD17B2GAA | |
| SCHEMBL2197492 | 0.79 | GCK (0.67) | GCK | |
| SCHEMBL2197476 | 0.79 | GCK (0.67) | GCK | |
| SCHEMBL3352943 | 0.75 | GCK (0.42) | GCKCCR5 | |
| SCHEMBL2224418 | 0.75 | GCK (0.42) | GCKCCR5 | |
| SCHEMBL3350994 | 0.73 | GCK (0.47) | GCKGAA | |
| SCHEMBL2384776 | 0.71 | GCK (0.41) | GCKKMT2AHSD17B1HSD17B2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010029461-A1 | HETEROARYLS AMIDE DERIVATIVES AND THEIR USE AS GLUCOKINASE ACTIVATORS | PFIZER INC. (US) | 2010-03-18 | — | — | WO | disclosed |