Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 13/20 | 0.62 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3354090 | 1.00 | KCNH2 (0.62) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL3351171 | 1.00 | KCNH2 (0.62) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL19094015 | 1.00 | KCNH2 (0.62) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL2686844 | 0.93 | KCNH2 (0.56) | KCNH2 | |
| SCHEMBL5021668 | 0.93 | KCNH2 (0.56) | KCNH2 | |
| SCHEMBL13767093 | 0.93 | KCNH2 (0.56) | KCNH2 | |
| Hydrochloric Acid SCHEMBL2688137 | 0.92 | KCNH2 (0.56) | KCNH2 | |
| Hydrochloric Acid SCHEMBL9987816 | 0.92 | KCNH2 (0.56) | KCNH2 | |
| Hydrochloric Acid SCHEMBL2687046 | 0.92 | KCNH2 (0.56) | KCNH2 | |
| SCHEMBL3353783 | 0.88 | KCNH2 (0.62) | KCNH2KCNQ1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120270864-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE-DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB | 2012-10-25 | — | — | US | disclosed |
| US-20100144717-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE-DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144717-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE-DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | NQO2, SDHA, NDUFS5 | KCNH2 466/4885KCNQ1 155/4885CACNA1C 2931/4885 |
| US-20120270864-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE-DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | NQO2, SDHA, NDUFS5 | KCNH2 466/4885KCNQ1 155/4885CACNA1C 2931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.