Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363298 | 0.95 | ZAP70 (0.47) | ZAP70SYKTLR7GSK3BDYRK1A | |
| SCHEMBL3359111 | 0.95 | ZAP70 (0.52) | ZAP70SYKTLR7GSK3BDYRK1A | |
| SCHEMBL3362351 | 0.88 | ZAP70 (0.49) | ZAP70SYKTLR7EGFRLCK | |
| SCHEMBL3360188 | 0.88 | ZAP70 (0.48) | ZAP70SYKEGFRLCKJAK3 | |
| SCHEMBL3362595 | 0.88 | ZAP70 (0.48) | ZAP70SYKEGFRLCKJAK3 | |
| SCHEMBL3358518 | 0.88 | ZAP70 (0.53) | ZAP70SYKEGFRJAK3ROCK2 | |
| SCHEMBL3362028 | 0.87 | ZAP70 (0.49) | ZAP70SYKTLR7EGFRLCK | |
| SCHEMBL3359671 | 0.87 | ZAP70 (0.46) | ZAP70SYKMAP4K1 | |
| SCHEMBL3359391 | 0.87 | ZAP70 (0.44) | ZAP70SYKEGFRLCKJAK3 | |
| SCHEMBL3362403 | 0.86 | ZAP70 (0.68) | ZAP70SYKTLR7GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |