Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358601 | 0.95 | ZAP70 (0.49) | ZAP70SYKMAP4K1GSK3BDYRK1A | |
| SCHEMBL3359671 | 0.91 | ZAP70 (0.46) | ZAP70SYKMAP4K1MAP4K3BRD4 | |
| SCHEMBL3362351 | 0.91 | ZAP70 (0.49) | ZAP70SYKMAP4K1EGFRLCK | |
| SCHEMBL3363298 | 0.91 | ZAP70 (0.47) | ZAP70SYKGSK3BDYRK1AEGFR | |
| SCHEMBL3362595 | 0.91 | ZAP70 (0.48) | ZAP70SYKEGFRLCKJAK3 | |
| SCHEMBL3360188 | 0.91 | ZAP70 (0.48) | ZAP70SYKEGFRLCKJAK3 | |
| SCHEMBL3358518 | 0.91 | ZAP70 (0.53) | ZAP70SYKEGFRJAK3KCNH2 | |
| SCHEMBL3362028 | 0.90 | ZAP70 (0.49) | ZAP70SYKEGFRLCKJAK3 | |
| SCHEMBL3362403 | 0.89 | ZAP70 (0.68) | ZAP70SYKGSK3BDYRK1AEGFR | |
| SCHEMBL3359635 | 0.89 | ZAP70 (0.53) | ZAP70SYKGSK3BEGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |