Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | DAO | P14920 | 2/20 | 0.56 |
| ▸ | DDO | Q99489 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30590365 | 0.80 | AURKA (0.53) | AURKAPARP1DAOFGFR1FLT1 | |
| SCHEMBL25432963 | 0.80 | AURKA (0.53) | AURKAPARP1DAOFGFR1FLT1 | |
| SCHEMBL3358664 | 0.78 | AURKA (0.54) | AURKAPARP1DAOALDH1A1FEN1 | |
| SCHEMBL14224041 | 0.77 | AURKA (0.57) | AURKAPARP1DAOFGFR1FLT1 | |
| SCHEMBL4518985 | 0.76 | AURKA (0.53) | AURKAPARP1DAOFGFR1FLT1 | |
| SCHEMBL6101270 | 0.76 | GRIN2D (0.58) | AURKAPARP1DAOFGFR1FLT1 | |
| SCHEMBL6103937 | 0.75 | FGFR1 (0.57) | AURKAPARP1DAOFGFR1FLT1 | |
| SCHEMBL7976276 | 0.75 | KDM4E (0.46) | AURKAPARP1ALDH1A1FEN1KDM4E | |
| SCHEMBL855363 | 0.74 | KDM4E (0.50) | AURKAPARP1ALDH1A1FEN1KDM4E | |
| SCHEMBL30324482 | 0.74 | KDM4E (0.50) | AURKAPARP1ALDH1A1FEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010058314-A1 | HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010058314-A1 | HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 2010-05-27 | — | — | WO | disclosed |