Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358656 | 0.78 | AURKA (0.57) | AURKAPARP1PKMALDH1A1FEN1 | |
| SCHEMBL25432963 | 0.77 | AURKA (0.53) | AURKAPARP1ALDH1A1POLBFEN1 | |
| SCHEMBL30590365 | 0.77 | AURKA (0.53) | AURKAPARP1ALDH1A1POLBFEN1 | |
| SCHEMBL8326093 | 0.77 | AURKA (0.47) | AURKAPARP1PKMALDH1A1POLB | |
| SCHEMBL14224041 | 0.74 | AURKA (0.57) | AURKAPARP1ALDH1A1FEN1ADORA2A | |
| SCHEMBL3453881 | 0.74 | AURKA (0.61) | AURKAPARP1PKMALDH1A1POLB | |
| SCHEMBL30324482 | 0.72 | KDM4E (0.50) | AURKAPARP1ALDH1A1FEN1KDM4E | |
| SCHEMBL855363 | 0.72 | KDM4E (0.50) | AURKAPARP1ALDH1A1FEN1KDM4E | |
| SCHEMBL7965829 | 0.72 | MAP2K1 (0.54) | AURKAPARP1ALDH1A1POLBFEN1 | |
| SCHEMBL16497388 | 0.71 | MAP2K1 (0.46) | AURKAPARP1PKMALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010058314-A1 | HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 2010-05-27 | — | — | WO | disclosed |