Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 10/20 | 0.51 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | FER | P16591 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1048495 | 0.91 | ZAP70 (0.45) | ZAP70JAK1JAK2FERLYN | |
| SCHEMBL1047313 | 0.88 | ZAP70 (0.51) | ZAP70JAK1JAK2FERLYN | |
| SCHEMBL1049152 | 0.87 | ZAP70 (0.49) | ZAP70JAK1JAK2FERJAK3 | |
| SCHEMBL1045667 | 0.87 | ZAP70 (0.47) | ZAP70JAK1JAK2FERLYN | |
| SCHEMBL1046592 | 0.87 | ZAP70 (0.61) | ZAP70JAK1JAK2SYK | |
| SCHEMBL1047758 | 0.86 | ZAP70 (0.46) | ZAP70JAK1JAK2FERSYK | |
| SCHEMBL1048284 | 0.86 | ZAP70 (0.51) | ZAP70JAK1JAK2FERLYN | |
| SCHEMBL28790499 | 0.85 | ZAP70 (0.56) | ZAP70JAK1JAK2FERTYK2 | |
| SCHEMBL1047764 | 0.84 | ZAP70 (0.58) | ZAP70JAK1JAK2FERLYN | |
| SCHEMBL1047972 | 0.84 | ZAP70 (0.45) | ZAP70JAK1JAK2FERLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |