Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 6/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359025 | 0.83 | SYK (0.42) | ZAP70SYKJAK3 | |
| SCHEMBL3360029 | 0.81 | PTK2 (0.42) | ZAP70SYKJAK3 | |
| SCHEMBL3360308 | 0.81 | SYK (0.44) | ZAP70SYKJAK3EGFRLCK | |
| SCHEMBL3362948 | 0.81 | JAK3 (0.36) | ZAP70SYKCDK1CDK4CCNA2 | |
| SCHEMBL1047562 | 0.80 | ZAP70 (0.59) | ZAP70SYK | |
| SCHEMBL3362887 | 0.79 | ZAP70 (0.46) | ZAP70SYKCYP3A4CYP2C9FGFR3 | |
| SCHEMBL3362704 | 0.79 | ZAP70 (0.40) | ZAP70SYKJAK3EGFRLCK | |
| SCHEMBL3360759 | 0.78 | SYK (0.36) | ZAP70SYKMAP4K1CYP3A4CYP2C9 | |
| SCHEMBL3362632 | 0.77 | ZAP70 (0.45) | ZAP70SYKMAP4K1 | |
| SCHEMBL3362166 | 0.77 | ZAP70 (0.49) | ZAP70SYKJAK3EGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |