Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359173 | 0.87 | ALK (0.39) | SYKJAK3PTK2EGFRLCK | |
| SCHEMBL3362948 | 0.82 | JAK3 (0.36) | SYKJAK3PTK2EGFRLCK | |
| SCHEMBL3359883 | 0.82 | FGFR1 (0.34) | SYKJAK3PTK2EGFRLCK | |
| SCHEMBL3359025 | 0.80 | SYK (0.42) | SYKJAK3PTK2ALKZAP70 | |
| SCHEMBL3360029 | 0.80 | PTK2 (0.42) | SYKJAK3PTK2ALKZAP70 | |
| SCHEMBL3362350 | 0.79 | ALK (0.38) | SYKJAK3PTK2EGFRLCK | |
| SCHEMBL1050369 | 0.78 | ZAP70 (0.56) | SYKJAK3PTK2ZAP70JAK2 | |
| SCHEMBL3360308 | 0.78 | SYK (0.44) | SYKJAK3EGFRLCKBTK | |
| SCHEMBL3359627 | 0.78 | MAP4K1 (0.42) | PTK2EGFRBTKALKZAP70 | |
| SCHEMBL3359068 | 0.78 | ZAP70 (0.39) | SYKJAK3EGFRLCKZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |