Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 13/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.93 |
| ▸ | MEN1 | O00255 | 1/20 | 0.93 |
| ▸ | RGS12 | O14924 | 1/20 | 0.93 |
| ▸ | NPC1 | O15118 | 1/20 | 0.93 |
| ▸ | USP2 | O75604 | 1/20 | 0.93 |
| ▸ | LMNA | P02545 | 1/20 | 0.93 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.93 |
| ▸ | THRB | P10828 | 1/20 | 0.93 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.93 |
| ▸ | HTT | P42858 | 1/20 | 0.93 |
| ▸ | RAD52 | P43351 | 1/20 | 0.93 |
| ▸ | RAB9A | P51151 | 1/20 | 0.93 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.93 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.93 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.93 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.93 |
| ▸ | BCHE | P06276 | 13/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL565418 | 1.00 | KDM4E (0.93) | KDM4EMEN1RGS12NPC1USP2 | |
| Bromide SCHEMBL3359440 | 1.00 | KDM4E (0.93) | KDM4EMEN1RGS12NPC1USP2 | |
| Bromide SCHEMBL3360044 | 1.00 | KDM4E (0.93) | KDM4EMEN1RGS12NPC1USP2 | |
| Bromide SCHEMBL3359702 | 1.00 | KDM4E (0.93) | KDM4EMEN1RGS12NPC1USP2 | |
| SCHEMBL1412685 | 0.98 | KDM4E (0.97) | KDM4EMEN1RGS12NPC1USP2 | |
| SCHEMBL9319117 | 0.98 | KDM4E (0.97) | KDM4EMEN1RGS12NPC1USP2 | |
| SCHEMBL29721510 | 0.98 | KDM4E (0.97) | KDM4EMEN1RGS12NPC1USP2 | |
| SCHEMBL4061564 | 0.98 | KDM4E (0.97) | KDM4EMEN1RGS12NPC1USP2 | |
| SCHEMBL1963218 | 0.98 | KDM4E (0.97) | KDM4EMEN1RGS12NPC1USP2 | |
| SCHEMBL1412766 | 0.98 | KDM4E (0.97) | KDM4EMEN1RGS12NPC1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023219492-A1 | PROLINOL BROMIDE AS BROMINE COMPLEXING AGENT IN BATTERY APPLICATIONS | TECHNISCHE UNIVERSITEIT DELFT (NL) | 2023-11-16 | — | — | WO | claimed |
| US-8367358-B2 | Reagent, kit and method for differentiating and counting leukocytes | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2013-02-05 | — | — | US | claimed |
| US-20100151509-A1 | REAGENT, KIT AND METHOD FOR DIFFERENTATING AND COUNTING LEUKOCYTES | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2010-06-17 | — | — | US | claimed |
| WO-2023219492-A1 | PROLINOL BROMIDE AS BROMINE COMPLEXING AGENT IN BATTERY APPLICATIONS | TECHNISCHE UNIVERSITEIT DELFT (NL) | 2023-11-16 | — | — | WO | disclosed |
| CN-113385227-B | Polyacid-based photocatalyst and preparation method and application thereof | 清华大学 | 2022-07-05 | — | — | CN | disclosed |
| CN-113385227-A | Polyacid-based photocatalyst and preparation method and application thereof | 清华大学 | 2021-09-14 | — | — | CN | disclosed |
| US-8367358-B2 | Reagent, kit and method for differentiating and counting leukocytes | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2013-02-05 | — | — | US | disclosed |
| US-20100151509-A1 | REAGENT, KIT AND METHOD FOR DIFFERENTATING AND COUNTING LEUKOCYTES | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2010-06-17 | — | — | US | disclosed |
| US-4028268-A | QUATERNIZED CYCLIC NITROGEN BASE, ACETYLENIC ALCOHOL, SURFACTANT, FORMIC ACID DERIVATIVE | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1977-06-07 | — | — | US | disclosed |