Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | NEK2 | P51955 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.47 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2349 | 0.98 | SIGMAR1 (0.63) | SIGMAR1MCL1KDM4EGAAMAPT | |
| SCHEMBL27737084 | 0.98 | SIGMAR1 (0.63) | SIGMAR1MCL1KDM4EGAAMAPT | |
| SCHEMBL29364795 | 0.98 | SIGMAR1 (0.63) | SIGMAR1MCL1KDM4EGAAMAPT | |
| SCHEMBL29555314 | 0.98 | SIGMAR1 (0.63) | SIGMAR1MCL1KDM4EGAAMAPT | |
| Hydrochloric Acid SCHEMBL28099546 | 0.95 | SIGMAR1 (0.61) | SIGMAR1MCL1KDM4EGAAMAPT | |
| SCHEMBL2174491 | 0.95 | SIGMAR1 (0.61) | SIGMAR1MCL1KDM4EGAAMAPT | |
| Hydrochloric Acid SCHEMBL2866027 | 0.95 | SIGMAR1 (0.61) | SIGMAR1MCL1KDM4EGAAMAPT | |
| Hydrochloric Acid SCHEMBL31515359 | 0.95 | SIGMAR1 (0.61) | SIGMAR1MCL1KDM4EGAAMAPT | |
| SCHEMBL2173531 | 0.95 | SIGMAR1 (0.61) | SIGMAR1MCL1KDM4EGAAMAPT | |
| Nitrogen SCHEMBL27346241 | 0.93 | SIGMAR1 (0.59) | SIGMAR1MCL1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8816095-B2 | Na channels, disease, and related assays and compositions | GEORGETOWN UNIVERSITY (US) | 2014-08-26 | — | — | US | disclosed |
| WO-2010027641-A2 | NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS | GEORGETOWN UNIVERSITY (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010019963-A2 | NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS | GEORGETOWN UNIVERSITY (US) | 2010-02-18 | — | — | WO | disclosed |