Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 6/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362166 | 0.92 | ZAP70 (0.49) | ZAP70SYKBRD4ATAD2TLR9 | |
| SCHEMBL3362296 | 0.89 | ZAP70 (0.49) | ZAP70BRD4 | |
| SCHEMBL3362930 | 0.85 | TLR7 (0.36) | ZAP70SYKBRD4ATAD2TLR9 | |
| SCHEMBL3362102 | 0.85 | SYK (0.39) | ZAP70SYKBRD4ATAD2LRRK2 | |
| SCHEMBL3362908 | 0.84 | ZAP70 (0.37) | ZAP70SYKBRD4ATAD2LRRK2 | |
| SCHEMBL3363030 | 0.84 | ZAP70 (0.39) | ZAP70SYKBRD4ATAD2MAP3K12 | |
| SCHEMBL3358208 | 0.84 | TLR9 (0.40) | ZAP70BRD4ATAD2TLR9TLR8 | |
| SCHEMBL3357921 | 0.83 | ZAP70 (0.47) | ZAP70BRD4EGFRLCKJAK3 | |
| SCHEMBL3358316 | 0.82 | ZAP70 (0.39) | ZAP70SYKBRD4EGFRJAK3 | |
| SCHEMBL3362467 | 0.81 | ZAP70 (0.49) | ZAP70BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |