Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 4/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362166 | 0.91 | ZAP70 (0.49) | ZAP70SYKBRD4ATAD2INSR | |
| SCHEMBL3362708 | 0.89 | ZAP70 (0.49) | ZAP70SYKPDE10A | |
| SCHEMBL3359856 | 0.87 | ZAP70 (0.40) | ZAP70SYKAXLTYRO3MERTK | |
| SCHEMBL3359219 | 0.84 | ZAP70 (0.41) | ZAP70SYKMAP3K12BRD4ATAD2 | |
| SCHEMBL3356474 | 0.83 | ZAP70 (0.37) | ZAP70SYKPDE10AINSRALK | |
| SCHEMBL3363341 | 0.82 | SYK (0.41) | ZAP70SYK | |
| SCHEMBL3362099 | 0.80 | ZAP70 (0.45) | ZAP70SYKBRD4ATAD2INSR | |
| SCHEMBL1050524 | 0.79 | ZAP70 (0.64) | ZAP70SYKBRD4ATAD2 | |
| SCHEMBL3358232 | 0.78 | ZAP70 (0.46) | ZAP70SYKINSRALK | |
| SCHEMBL3360670 | 0.77 | ZAP70 (0.48) | ZAP70SYKINSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |