Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 9/20 | 0.34 |
| ▸ | FLT1 | P17948 | 4/20 | 0.34 |
| ▸ | FLT4 | P35916 | 4/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | KIT | P10721 | 6/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359578 | 0.88 | BTK (0.40) | BTKKDRFLT1FLT4HDAC1 | |
| SCHEMBL3357123 | 0.79 | BTK (0.35) | BTKKDRFLT1FLT4HDAC1 | |
| SCHEMBL3362540 | 0.77 | SYK (0.44) | KDRFLT1KITPDGFRACSF1R | |
| SCHEMBL1048441 | 0.77 | ZAP70 (0.41) | BTKFERFGFR2FLT3 | |
| SCHEMBL27826761 | 0.77 | BTK (0.35) | BTKKDRFLT1FLT4HDAC1 | |
| SCHEMBL3359543 | 0.68 | ZAP70 (0.40) | KDRKITCSF1RLCKFLT3 | |
| SCHEMBL3360279 | 0.67 | ABL1 (0.41) | KDRCSF1RAURKAJAK2ABL1 | |
| SCHEMBL3360065 | 0.66 | PIK3CG (0.41) | CYP3A4JAK2CYP1A2BRAFTYK2 | |
| SCHEMBL3362295 | 0.66 | ZAP70 (0.41) | BTKKDRKITTTKFLT3 | |
| SCHEMBL27826553 | 0.65 | BTK (0.36) | BTKKDRFLT1FLT4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |