Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 7/20 | 0.39 |
| ▸ | CD63 | P08962 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 4/20 | 0.34 |
| ▸ | JAK1 | P23458 | 4/20 | 0.34 |
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358946 | 0.92 | SYK (0.46) | PIK3CGSYKCD63ZAP70PIK3CA | |
| SCHEMBL3360824 | 0.89 | BRAF (0.40) | PIK3CGSYKCD63DHFRZAP70 | |
| SCHEMBL3359690 | 0.84 | PIK3CA (0.46) | PIK3CGSYKPIK3CAPIK3CBCYP1A2 | |
| SCHEMBL3358704 | 0.78 | PIK3CA (0.44) | PIK3CGSYKCD63ZAP70PIK3CA | |
| SCHEMBL3359807 | 0.78 | FYN (0.41) | SYKCD63PIK3CAPI4KBBRAF | |
| SCHEMBL3362036 | 0.76 | MAP3K11 (0.37) | PIK3CGSYKZAP70 | |
| SCHEMBL3362467 | 0.76 | ZAP70 (0.49) | ZAP70PIK3CA | |
| SCHEMBL3357832 | 0.75 | ZAP70 (0.42) | SYKZAP70 | |
| SCHEMBL1044934 | 0.74 | ZAP70 (0.51) | PIK3CGSYKCD63DHFRZAP70 | |
| SCHEMBL3358964 | 0.73 | ZAP70 (0.44) | SYKZAP70JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |