Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358518 | 0.89 | ZAP70 (0.53) | ZAP70SYKCYP11B2BTKBRD4 | |
| SCHEMBL3362051 | 0.88 | ZAP70 (0.44) | ZAP70SYKCYP11B1CYP11B2BTK | |
| SCHEMBL3358980 | 0.88 | ZAP70 (0.43) | ZAP70SYKCYP11B1CYP11B2BTK | |
| SCHEMBL3358964 | 0.86 | ZAP70 (0.44) | ZAP70SYKBTKBRD4CREBBP | |
| SCHEMBL3359108 | 0.86 | ZAP70 (0.44) | ZAP70SYKBTKBRD4CREBBP | |
| SCHEMBL3359665 | 0.85 | SYK (0.43) | ZAP70SYKCYP11B1CYP11B2BTK | |
| SCHEMBL3359747 | 0.84 | ENPP2 (0.44) | ZAP70SYKBTKEGFRJAK3 | |
| SCHEMBL3359078 | 0.83 | ZAP70 (0.39) | ZAP70SYKCYP11B1CYP11B2BTK | |
| SCHEMBL3359236 | 0.83 | ZAP70 (0.39) | ZAP70SYKCYP11B1CYP11B2BTK | |
| SCHEMBL3360647 | 0.82 | ZAP70 (0.43) | ZAP70SYKBTKBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |