Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.68 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.52 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18451966 | 0.85 | TGFBR1 (0.73) | TGFBR1TGFBR2THRBMAPK14 | |
| SCHEMBL412367 | 0.84 | TGFBR1 (0.94) | TGFBR1TGFBR2THRBMAPK14 | |
| SCHEMBL373822 | 0.81 | TGFBR1 (1.00) | TGFBR1TGFBR2THRBMAPK14 | |
| SCHEMBL412606 | 0.81 | TGFBR1 (0.69) | TGFBR1TGFBR2MAP3K20THRBMAPK14 | |
| SCHEMBL409714 | 0.80 | TGFBR1 (1.00) | TGFBR1TGFBR2THRBMAPK14 | |
| SCHEMBL412661 | 0.78 | TGFBR1 (0.85) | TGFBR1TGFBR2THRBMAPK14 | |
| SCHEMBL3359663 | 0.77 | TGFBR1 (0.92) | TGFBR1TGFBR2THRBMAPK14 | |
| SCHEMBL6111629 | 0.77 | TGFBR1 (0.76) | TGFBR1TGFBR2 | |
| SCHEMBL8324394 | 0.76 | TGFBR1 (0.88) | TGFBR1TGFBR2THRBMAPK14 | |
| SCHEMBL407846 | 0.75 | TGFBR1 (0.79) | TGFBR1TGFBR2THRBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-A1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2004-03-17 | — | — | EP | claimed |
| WO-2002094833-A1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2002-11-28 | — | — | WO | claimed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |
| EP-1397364-A1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002094833-A1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2002-11-28 | — | — | WO | disclosed |