Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380955 | 0.78 | DAO (0.65) | DAOPDE3BPDE3AGRIN2DGRIN3B | |
| SCHEMBL31398830 | 0.76 | BRD4 (0.59) | DAOGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL250338 | 0.76 | BRD4 (0.59) | DAOGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL22717634 | 0.76 | DAO (0.57) | DAOPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL24312093 | 0.75 | DAO (0.61) | DAOPDE3BPDE3AGRIN2DGRIN3B | |
| SCHEMBL3360519 | 0.75 | DAO (1.00) | DAOPDE3BPDE3APARP1HRH4 | |
| SCHEMBL21957317 | 0.75 | DAO (0.65) | DAOPDE3BPDE3APARP1CSNK2A1 | |
| SCHEMBL31475468 | 0.75 | DAO (0.65) | DAOPDE3BPDE3AKDM4EHPGD | |
| SCHEMBL22017082 | 0.74 | DAO (0.59) | DAOPDE3BPDE3AACHEPARP1 | |
| SCHEMBL22016192 | 0.74 | DAO (0.59) | DAOPDE3BPDE3APARP1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010058314-A1 | HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 2010-05-27 | — | — | WO | disclosed |