Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 3/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380955 | 0.78 | DAO (0.65) | DAOPDE3BPDE3ADYRK1APARP1 | |
| SCHEMBL24312485 | 0.76 | BRD4 (0.59) | DAOFGFR1MAPK1KDRMAPT | |
| SCHEMBL24312093 | 0.75 | DAO (0.61) | DAOPDE3BPDE3AMAPK1PARP1 | |
| SCHEMBL21957317 | 0.75 | DAO (0.65) | DAOPDE3BPDE3ACSNK2A1PIM1 | |
| SCHEMBL3360519 | 0.75 | DAO (1.00) | DAOPDE3BPDE3APARP1HRH4 | |
| SCHEMBL31475468 | 0.75 | DAO (0.65) | DAOPDE3BPDE3ACSNK2A1PIM1 | |
| SCHEMBL22016192 | 0.74 | DAO (0.59) | DAOPDE3BPDE3AMAPK1GSK3B | |
| SCHEMBL4310842 | 0.74 | DAO (0.59) | DAOPDE3BPDE3APARP1HRH4 | |
| SCHEMBL3359700 | 0.74 | DAO (0.59) | DAOPDE3BPDE3ACSNK2A1PRKCZ | |
| SCHEMBL28124188 | 0.74 | DAO (0.59) | DAOPDE3BPDE3ACSNK2A1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | DAO 4307/4885PDE3B 87/4885PDE3A 266/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | DAO 4307/4885PDE3B 87/4885PDE3A 266/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | DAO 4307/4885PDE3B 87/4885PDE3A 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.