Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3356239 | 0.94 | ROCK2 (0.56) | ROCK2ROCK1ALOX15ALOX12MTNR1A | |
| SCHEMBL3388227 | 0.86 | ROCK2 (0.67) | ROCK2 | |
| SCHEMBL3387705 | 0.84 | ROCK2 (0.45) | ROCK2ROCK1 | |
| SCHEMBL3359299 | 0.83 | ROCK2 (0.55) | ROCK2ROCK1ALOX15ALOX12AKT1 | |
| SCHEMBL3388663 | 0.82 | ROCK2 (0.51) | ROCK2ROCK1ALOX15ALOX12 | |
| SCHEMBL3355166 | 0.81 | ROCK2 (0.49) | ROCK2ROCK1ALOX15ALOX12 | |
| SCHEMBL13362739 | 0.80 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL3386714 | 0.80 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL13362854 | 0.80 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL1519127 | 0.78 | ROCK2 (0.62) | ROCK2ROCK1AKT1MAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |