Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.61 |
| ▸ | FLT3 | P36888 | 9/20 | 0.61 |
| ▸ | KIT | P10721 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3360963 | 0.91 | KDR (0.59) | KDRFLT3KITKDM4EPDGFRB | |
| SCHEMBL27657310 | 0.90 | KDR (0.59) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL3396670 | 0.87 | KDR (0.49) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL419414 | 0.83 | KDR (0.84) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL3399472 | 0.83 | KDR (0.60) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL418941 | 0.82 | KDR (0.62) | KDRFLT3KITALDH1A1KDM4E | |
| SCHEMBL27657317 | 0.81 | KDR (0.57) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL13372721 | 0.81 | KDR (0.57) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL27657309 | 0.81 | KDR (0.57) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL27636457 | 0.80 | KDR (0.57) | KDRFLT3KITPDGFRBCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638941-B1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LAB (US) | 2010-06-02 | — | — | EP | claimed |